We present a new ecosystem risk assessment model, the Comprehensive Assessment of Risk to Ecosystems (CARE), which allows analysts to consider the cumulative impact of multiple threats, interactions among threats that may result in synergistic or antagonistic impacts, and the impacts of a suite of threats on whole-ecosystem productivity and functioning, as well as on ecosystem services. CARE can be completed very rapidly, and uses local and expert knowledge where data are lacking. It can be applied to virtually any system, and can be modified as knowledge is gained or to better match different site characteristics.